Regulation of ubiquitin-proteasome-dependent protein breakdown in experimental models in muscle atrophy

Authors

  • Matjaž ČERVEK RCP Emona, Kavčičeva 72, SI-1000 Ljubljana, Slovenia
  • Didier ATTAIX INRA, Laboratorij za presnovo dušika, Center Clermont-Ferrand-Theix, F-63122 Saint-Genès-Champanelle, Francija
  • Jasna M. A. STEKAR Univ. of Ljubljana, Biotechnical Fac., Zootechnical Dept., Groblje 3, SI-1230 Domžale, Slovenia

DOI:

https://doi.org/10.14720/aas.1999.74.2.15866

Keywords:

proteins, protein breakdown, proteasom, ubiquitin, experimental models, skeletal muscle

Abstract

There is more and more evidence that ATP-ubiquitin-dependent proteolytic system has a key role in muscle protein breakdown. In different experimental models in muscle atrophy we try to define factors involved in regulation of ATP-ubiquitin-dependent proteolytic pathway. If we use a simplified division, we can talk about experimental models in which we use regulation by nutrients (fasting, protein inadequate diet), by disuse of muscle (denervation, weightlessness), by pathological conditions (sepsis, acidosis, diabetes, burn injury, cachexia), by hormones (insulin, IGF-1, glucocorticoids) and by cytokines (tumor necrosis factor-a, interleukin-1, interleukin-6).

Published

15. 12. 1999

Issue

Section

Review Article

How to Cite

ČERVEK, M., ATTAIX, D., & STEKAR, J. M. A. (1999). Regulation of ubiquitin-proteasome-dependent protein breakdown in experimental models in muscle atrophy. Acta Agriculturae Slovenica, 74(2), 7–14. https://doi.org/10.14720/aas.1999.74.2.15866

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