Using pyrimidinecarboxylic acids as growth stimulants for Rhododendron ledebourii Pojark and Rhododendron smirnowii Trautv.


  • Tatiana V. VOSTRIKOVA Voronezh State University, Voronezh
  • Andrey Yu. POTAPOV Voronezh State University, Voronezh
  • Nadezhda V. STOLPOVSKAYA Voronezh State University, Voronezh
  • Khidmet S. SHIKHALIEV Voronezh State University, Voronezh



growth stimulants, synthesized organic compounds, pyrimidine carboxylic acids, Rhododendron


Synthesised organic compounds of pyrimidinecarboxylic acids are characterised by high biological activity, even when their concentrations are low. These compounds, when applied to the seeds of Rhododendron, a genus of woody plants, with concentrations of 0.01, 0.05, and 0.1 %, stimulate the growth of the plants. The effect is more obvious 3 months after the start of the experiment, rather than 7 months after. Thus, Rhododendron ledebourii Pojark. seedlings grew by 13.3-33.5 %, and Rhododendron smirnowii Trautv. seedlings grew by 29.6-48.1 %. Rhododendron ledebourii and Rhododendron smirnowii seedlings demonstrated similar direct correlations: when the concentration of 2-benzylamino-4-methyl-pyrimidine-5-carboxylic acid and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid (for Rhododendron ledebourii seeds only) rose from 0.01 to 0.1 %, the height of the seedlings increased. It is suggested using 4-methyl-2-piperidin-1-yl-pyrimidine-5-carboxylic acid, 2-benzylamino-4-methyl-pyrimidine-5-carboxylic acid, and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid at concentrations of 0.01, 0.05, and 0.1 % as growth stimulants for the species of Rhododendron genus.


Alexandrova, M. S. (2003). Rhododendrons. ZAO Fiton+, Moscow, Russia.

Azizian, J., Delbari, A. S., One-Pot, K. Y. (2014). Three-component synthesis of pyrimido [4,5-b]quinoline-tetraone derivatives in water. Synthetic Communication, 44(22), 3277–3286.

Balalaie, S., Abdolmohammadi, S. Bijanzadeh, H. R., Amani, A. M. (2008). Diammonium hydrogen phosphate as a versatile and efficient catalyst for the one-pot synthesis of pyrano [2, 3-d] pyrimidinone derivatives in aqueous media. Molecular Diversity, 12, 85–91.

Baranova, T. V. (2013a). Accelerated production of plants resistant to urban conditions. Ecology and Industry of Russia, 4, 65–67 (Ru).

Baranova, T. V. (2013b). Phenological characteristics of species of the genus Rhododendron L. in the central black soil. Bulletin of Krasnoyarsk State Agrarian University, 4, 74–79 (Ru).

Bome, N. A., Weisfeld, L. I., Babaev, E.V., Bome, A. Ya., Kolokolova, N. N. (2017). Influence of phosphomid, a chemical mutagen, on agrobiologial signs of soft spring wheat Triticum aestivum L. Agricultural Biology, 52(3), 570-579 (Ru).

Brown, C. W., Liu, S., Klucik, J., Berlin, K. D., Brennan, P. J., Kaur, D., Benbrook, D. M. (2004). Novel heteroarotinoids as potential antagonists of Mycobacterium bovis BCG. Journal of Medicinal Chemistry, 47(4), 1008–1017.

Budykina, N. P., Drozdov, S. N., Kurets, V. K., Timeyko, L. V., Gafurov, R. G. (2005). The effect of etiol and benzihole on tomato plants due to changes in temperature conditions. Agricultural Chemistry, 4, 32-36 (Ru).

Burmenko, J. V., Baranova, T. V., Kalaev, V. N., Sorokopudov, V. N. (2018). Cytogenetic polymorphism of seed progeny of introduced plants on the example of Rhododendron ledebourii Pojark. Turczaninowia, (1), 164–173 (Ru).

Dlugosz, A., Dus, D. (1996). Synthesis and anticancer properties of pyrimido [4,5-b] quinolines. Farmaco, 51, 364–374.

El-Gazzar, A. B. A, Hafez, H. N., Nawwar, G. A. M. (2009). New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido [4,5-b]quinolines. European Journal of Medicinal Chemistry, 44(4), 1427–1436.

Elkholy, Y. M., & Morsy, M. A. (2006). Facile synthesis of 5, 6, 7, 8-tetrahydropyrimido [4, 5-b]- quinoline derivatives. Molecules, 11, 890–903.

Gafurov, R. G., Makhmutova, A. A. (2003). A new group of synthetic auxin biomimetics: N- and O-benzyl-containing compounds. Reports of the Russian Academy of Sciences, 391, 562-565 (Ru).

Gafurov, R. G., Makhmutova, A. A. (2005). Growth-regulating activity of Nand O-benzyl-containing compounds – a new group of synthetic analogues of natural auxins. Applied Biochemistry and Microbiology, 41(2), 245-249 (Ru).

Gavrilov, M. Y., Mardanova, L. G., Kolla, V. E., Konshin, M. E. (1988). Synthesis, antiinflammatory and analgesic activities of 2-arylamino-5,6,7,8-tetrahydroquinoline-3-carboxamides. Pharmaceutical Chemistry Journal, 22, 554–556.

Ghoneim, A. A., & Assy, M. G. (2015). Synthesis of some new hydroquinoline and pyrimido[4,5-b] quinoline derivatives. Current Research in Chemistry, 7(1), 14–20.

Goldmann, S., & Stoltefuss, J. (1991). 1,4-Dihydropyridines: Effects of chirality and conformation on the calcium antagonist and calcium agonist activities. Angewandte Chemie International Edition English, 30, 1559–1578.

Kalaev, V. N., Baranova, T. V., Potapov, A. Yu., Shikhaliev, H. S. (2013a). The method of using compounds of a number of pyrimidine-carboxylic acids as a growth promoter for annual marigold rejected: Patent 2490893. Russian Federation. 2012112008/13, declared 29.03.12, published 27.08.13, 24.

Kalaev, V. N., Moiseeva, E. V., Baranova, T. V., Medvedeva, S. M., Shikhaliev, H. S., Voronin, A. A. (2013b). Growth stimulants for species of the genus Rhododendron L.: Patent 2490892. Russian Federation. 2012112006/13, declared 29.03.12, published 27.08.13, 24.

Khodaei-Joghan, A., Gholamhoseini, M., Agha-Alikhani, M., Habibzadeh, F., Sorooshzadeh, A., Ghalavand, A. (2018). Response of sunflower to organic and chemical fertilizers in different drought stress conditions. Acta agriculturae Slovenica, 111(2), 271–284.

Korovkin, O. A. (2007). Anatomy and morphology of higher plants: a dictionary of terms. Drofa, Moscow, Russia.

Kulaichev, A. P. (2006). Methods and tools for integrated data analysis. FORUM: INFA-M, Moscow, Russia.

Lakin, G. F. (1990). Biometry. Higher School, Moscow, Russia.

Litvinov, V. P. (1998). Partially hydrogenated pyridinechalcogenones. Russian Chemistry Bulletin, 47, 2053–2073.

Marjani, A. P., Khalafy, J., Ebrahimlo, A. M. R. (2011). Facile synthesis of some new pyrimidoquinolines. Synthetic Communications, 41(16), 2475–2482.

Moiseeva, E. V., Baranova, T. V., Kalaev, V. N., Kuznetsov, B. I., Shcherbakov, G. S., Voronin, A. A., … Shikhaliev, H. S. (2012a). The effect of compounds of the quinoline series on the germination and growth processes of Ledebour’s rhododendron (Rhododendron ledebourii Pojark.). Basic Research, 5(1), 172–176 (Ru).

Moiseeva, E. V., Baranova, T. V., Voronin, A. A., Kuznetsov, B. I. (2012b). A collection of representatives of the genus rhododendron (Rhododendron L.) in the botanical garden B.M. Kozo-Polyansky Voronezh State University. Ecosystems, Their Optimization & Protection, 7, 39–44 (Ru).

Nesterkina, I. S., Musalov, M. V., Gurina, V. V., Ozolina, N. V., Spiridonova, E. V., Tretyakova, A. V., … Yakimov, V. A. (2019). The effect of a new non-toxic water-soluble selenorganic substance on antioxidant protection and development of seedlings of oilseed radish (Raphanus sativus L. var. oleiferus Metzg.). Acta agriculturae Slovenica, 114(1), 61–67.

Ostroshenko, V. V., & Ostroshenko, L. Yu. (2011). Influence of the seed pretreatment with growth stimulators on their sowing qualities. Bulletin of Krasnoyarsk State Agrarian University, 5, 12–15 (Ru).

Pentelkina, Yu. S. (2003). The influence of stimulators on the germination of seeds and the growth of seedlings of Pinophyta plants. PhD in Agriculture thesis, Moscow, Russia.

Schuchka, R. V. (2006). The effect of biopreparations and growth stimulators, as well as their application methods, on the yield and the quality of soy seeds in the Central Black Earth region. PhD in Agriculture thesis, Voronezh, Russia.

Shibaeva, T. G., Sherudilo, E. G., Ikonen, E. N., Titov, A. F. (2018). Responses of young cucumber plants to a diurnal temperature drop at different times of day and night. Acta agriculturae Slovenica, 111(3), 567–573.

Tkachenko, E. V., Gubar, S. N., Zhuravel, I. A., Datkhaev, U. M., Zhakipbekov, K. S. (2018). Synthesis and antimicrobial activity of amides 2,4-dioxo-1,4-dihydro-2H-thieno [3,2-d] pyrimidin-3yl) carboxylic acids. Bulletin of the Kazakh National Medical University, 1, 347–350 (Ru).

Tkachenko, E. V., Vlasov, S. V., Zhuravel, I. A., Kovalenko, S. N., Chernykh, V. P. (2013). Synthesis and antimicrobial activity of 2-alkylthio-3-N substituted thieno [3, 2-D] pyrimidin-4 (3H)–ones. Scientific Reports of Belgorod State University. Series: Medicine. Pharmacy, 24(1), 25(168), 133–139 (Ru).

Timeyko, L. V., Drozdov, S. N., Budykina, N. P., Gafurov, R. G. (2005). The effect of etiol on the thermal resistance and productivity of cucumber in spring film greenhouses in Karelia. Agricultural Chemistry, 7, 36-42 (Ru).

Vasin, A. V., Darmin, A. V., Brezhnev, V. V. (2009). Using growth stimulators for corn and barley growing. Fodder Production, 2, 17–18 (Ru).

Vasin, V. G., Darmin, A. V., Vasin, A. V. (2008). Effective use of growth stimulators for corn growing. Proceedings of Samara State Agrarian University, 4, 22–24 (Ru).

Vostrikova, T. V. (2011). Ecological and biological features of rhododendrons during introduction in the conditions of the Central Chernozem region. Bulletin of Krasnoyarsk State Agrarian University, 4, 27–30 (Ru).

Vostrikova, T. V., Burmenko, J. V., Kalaev, V. N., Sorokopudov, V. N. (2022). Anthropogenic Pollution Influence on the Antioxidant Activity in Leaves and on the Cytogenic Structures in the Seedlings of the Representatives of the Rhododendron Genus. In E. M. Lisitsyn, L. I. Weisfeld, A. I. Opalko (Eds.), Biological Assessment of Natural and Anthropogenic Ecosystems: Trends in Diagnosis of Environmental Stress (121-136). Burlington, Apple Academic Press Inc.

Vostrikova, T. V., Kalaev, V. N., Potapov, A. Yu., Shikhaliev, H. S. (2012). The effect of new synthesized chemical compounds of a number of pyrimidine carboxylic acids on the growth activity of Tagetes patula L. Bulletin of Voronezh State University. Seria. Chemistry. Biology. Pharmacy, 2, 132–135 (Ru).

Vostrikova, T. V., Kalaev, V. N., Potapov, A. Yu., Manakhelokhe, G. M., Shikhaliev, K. S. (2021) Use of new compounds of the quinoline series as growth and yield stimulants of agricultural crop. Periódico Tchê Química, 18(38), 123-136.

Vostrikova, T. V., Kalaev, V. N., Potapov, A. Yu., Potapov, M. A., Shikhaliev, K. S. (2020) Use of new compounds of the quinoline series as effective stimulants of growth processes. Periódico Tchê Química, 17(35), 781-790.

Weisfeld L. I. (2015). About cytogenetic mechanism of chemical mutagenesis. In A. I. Opalko, L. I. Weisfeld, S. A. Bekuzarova, N. A. Bome, G. E. Zaikov (Eds.), Ecological consequences of increasing crop productivity. Plant breeding and biotic diversity (259-269). Toronto-New Jersey, Apple Academic Press Inc.



13. 12. 2023



Original Scientific Article

How to Cite

VOSTRIKOVA, T. V., POTAPOV, A. Y., STOLPOVSKAYA, N. V., & SHIKHALIEV, K. S. (2023). Using pyrimidinecarboxylic acids as growth stimulants for Rhododendron ledebourii Pojark and Rhododendron smirnowii Trautv. Acta Agriculturae Slovenica, 119(4), 1–10.

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