β-lactam antibiotics, recA mutation and SOS response
DOI:
https://doi.org/10.14720/abs.58.1.15600Keywords:
SOS response, E. coli, β-lactam antibiotics, antibiotic resistanceAbstract
The claim that β-lactam antibiotics induce the SOS response, allowing E. coli survival in the presence of low antibiotic concentrations, was evaluated. No association between the recA gene and antibiotic survival rate was found. Disagreements with published observations are attributed to discrepancy in minimum inhibitory concentrations and growth characteristics of various strains carrying the recA mutation. Moreover, β-lactam antibiotics do not induce expression of the SOS regulated gene cka, encoding colicin K in wild-type strains.
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