Adaptive mutation: shall we survive bacterial genetic skills?


  • Rok Krašovec
  • Igor Jerman



adaptive mutation, inducible mutagenesis, transposable elements, signal transduction network, neo-darwinism


The origin and dynamics of genetic variations is one of the key questions in the modem science that has still not come out with a final answer. Emerging concepts regarding genetic variation have always produced a great controversy because they hold a key to unlock a great mystery of evolution. With such a powerful motivation scientist working in the molecular biology, genetics and biochemistry gathered a vast amount of experimental data showing us that a genome is a dynamic, hierarchically organized and complex integrated system for storing and processing information. Dynamic balance between stability and mutability of DNA nucleotide sequences is essential for a proper functioning of the organism. Beside many DNA repairing proteins and DNA protective mechanisms organisms possess also biochemical systems capable of changing DNA information. One of the most controversial and at the same time the most informative one is a phenomenon called adaptive mutation. We shall review findings concerning the phenomenon of adaptive mutation in prokaryotes and point out an urgent need for the upgrade of the awkward neo-darvinistic view on the origin .of the genetic variation.


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Krašovec, R., & Jerman, I. (2002). Adaptive mutation: shall we survive bacterial genetic skills?. Acta Biologica Slovenica, 45(2), 15-24.

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